If your nervous system feels like it’s hanging on by a single iced coffee and a prayer right now…welcome to the end-of-school-year chaos known as Maycember. Between competing family schedules, summer logistics, work deadlines, and the 47 tabs open in your brain, midlife stress can feel relentless.
And perimenopause and menopause can make stress hit harder. As estrogen and progesterone fluctuate, so do mood-regulating brain chemicals like serotonin. Translation? The things you used to brush off suddenly feel overwhelming.
On top of that, cortisol levels tend to rise during midlife, leaving many women wired, anxious, irritable, exhausted—or somehow all four at once.
Need a little help making it to summer slow-down season? Certain supplements can help you keep your calm during this hectic time:
Magnesium: Supports relaxation and sleep
L-theanine: Promotes calm without drowsiness
Lavender: May help ease tension
Ashwagandha: Helps the body manage stress
Midi’s Daily Cortisol Support: Combines multiple stress-supportive ingredients in one daily formula
And if supplements alone aren’t cutting it, your Midi clinician can help you explore other options—including hormone therapy (HRT) and testosterone—to better manage midlife stress and anxiety.
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Cortisol-triggering foods: What to know and what to swap
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How long does HRT take to work? Here’s what you can expect
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All about menopause mood swings: Triggers, tips, and treatments
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Midi in the News
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When Midi’s CEO Joanna Strober and other members of the team met with FDA leaders last week to address the growing estrogen patch shortage, they made one thing clear: this is not a “blip.” Nearly 8,000 women across 49 states responded to our survey in just four days, with 44% reporting
trouble filling prescriptions and 11% stopping treatment entirely.
As more women turn to evidence-based midlife care, manufacturers must expand production to meet rising demand—and Midi will continue advocating for the access and treatment women deserve.
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Trending Topics
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🚨New supplement alert🚨Midi just dropped Daily Omega-3+, a powerhouse blend of nutrients designed to support heart, brain, bone, and skin health
Dr. Mary Claire breaks down the science behind why the viral Pepcid + Zyrtec combo seems to help some women find relief from midlife symptoms
Perimenopause body odor change is totally normal, especially now that the weather is warming up, but there are simple ways to get back to your signature scent
Menopause and perimenopause are (finally!) moving from punchline to plotline, with newer series like “Your Friends & Neighbors” treating “the change” as a real, relatable part of women’s lives
Mood swings during midlife are common, but if you have intense feelings of sadness or irritability before your period, it could be PMDD (and thankfully, relief is possible)
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Kathleen Jordan |
Midi’s Chief Medical Officer
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“I don’t react well to the estradiol patch. Is oral estrogen an option? I’ve heard it’s unsafe.”
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Short answer: yes it’s an option—and for most women, it’s safe.
The difference between the two forms of hormone therapy (HRT) comes down to how your body processes them. Patches deliver estrogen through the skin directly into the bloodstream, while pills go through the digestive system and liver first. Because of that, oral estrogen is linked to a slightly higher risk of blood clots, which is one of the reasons why patches are often the first choice—especially if you have certain risk factors.
But for many healthy women, that increased risk is still very small—lower than the risk associated with taking birth control pills—and worth it for symptom relief. However, oral estrogen and the patch aren’t your only options. A Midi clinician can walk you through the other forms of HRT (such as creams and gels) to help you find the right fit.
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