Short answer: no. Research hasn’t found a link between hormone replacement therapy (HRT) and weight gain—and for many women, the opposite happens. Studies show that after starting HRT, women often lose belly fat and improve their waist-to-hip ratio in just a few months.

And the benefits go beyond the scale: think better sleep, a more stable mood, and less joint pain. When your hormones are supported, it’s easier to move your body, eat well, and feel like yourself again—all of which can support healthy weight loss.

If the scale does creep up while you’re on HRT, it’s not a failure or dead end. A Midi clinician can review your Care Plan and make targeted adjustments, like fine-tuning your HRT dose, adding a personalized GLP-1 prescription (research shows HRT combined with a GLP-1 can lead to better weight-loss results), or suggesting nutrition tweaks (yes, sometimes it really is as simple as more fiber), so your symptoms ease up—and your weight goals stay on track.